Legacy supply chain systems were built for predictability, not today's constant disruption. This session examines how real-time digital twins and enterprise AI are reshaping planning and execution by enabling continuous, intelligent decision-making across production, inventory and logistics. It will also explore how human teams and AI agents can work together in agentic workflows that combine machine speed with human judgement. Attendees will walk away understanding how AI agents deliver transparent, explainable insights that augment human judgement---helping organizations evolve from manual intervention toward true operational autonomy.